Sotrovimab for treating COVID-19 – Medical News Bulletin

Sotrovimab – a treatment for COVID-19 – is an antibody therapy that has been created to attach to the spike protein of the SARS-CoV-2 virus. It is administered as an IV infusion, in one dose. 

In pre-clinical animal studies, researchers confirmed that this antibody is able to bind to and ‘neutralize’ SARS-CoV-2. This means that by binding to the spike protein, the antibodies prevent the spike protein from binding to the ACE2 receptor and prevent the virus’ entry into cells. 

In a clinical trial, patients were randomly assigned to treatment groups. Specifically, the trial included patients who were unvaccinated and who were at high risk of complications from a COVID-19 infection. 

The study of 583 patients reported that sotrovimab treatment was able to reduce hospitalization and death in patients at risk of severe COVID-19. 

Some side effects that are most common with this type of treatment include infusion-related reactions, for example, fever or chills, nausea and vomiting. 

What about variants?

As the pandemic continues and more variants begin to circulate, there is some concern that vaccines and treatments may not be as effective against the SARS-CoV-2 virus. 

In pre-clinical studies, researchers were able to confirm that sotrovimab is able to bind to and neutralize the virus – even variants of concern.


  1. Sotrovimab for COVID-19. (2021). Australian prescriber44(5), 175.
  2. Brobst B, Borger J. Benefits And Risks Of Administering Monoclonal Antibody Therapy For Coronavirus (COVID-19) [Updated 2021 Aug 30]. In: StatPearls [Internet]. Treasure Island (FL): StatPearls Publishing; 2021 Jan-. Available from:
  3. Dolgin E. (2021). ‘Super-antibodies’ could curb COVID-19 and help avert future pandemics. Nature biotechnology39(7), 783–785.
  4. Image by PIRO4D from Pixabay 

Source Link


This blog is for information purposes only. The content is not intended as medical advice, diagnosis, or treatment. Should you have a medical or dermatological problem, please consult with your physician. None of the information or recommendations on this website should be interpreted as medical advice.

All product reviews, recommendations, and references are based on the author’s personal experience and impressions using the products. All views and opinions are the author’s own.

This blog post may contain affiliate links. An affiliate link means we may earn a commission if you click on a link and make a purchase, without any extra cost to you.

Please see our Disclaimer for more information.


The leading source for trustworthy and timely health and medical news and information. Providing credible health information, supportive community, and educational services by blending award-winning expertise in content, community services, expert commentary, and medical review. Everything about health is here with the difference of Dr.About

Related Articles

Leave a Reply

Back to top button